[Toxicity of matrine in Kunming mice].
Copyright policy )[Toxicity of matrine in Kunming mice].
To investigate the acute toxicity and assess the median lethal dose (LD50) of matrine in Kunming mice.Matrine at different doses were administered in Kunming mice via intraperitoneal injection, and the toxic reactions and LD50 of matrine was observed and determined.The acute toxicity test of matrine indicated that the tolerable dose of matrine was above 80 mg/kg in Kunming mice, and the LD50 was 157.13 mg/kg (95%CI, 88.08-280.31 mg/kg). Morphological observation revealed degenerative changes of the nerve cells in the brain tissue of the mice.The nervous system is the main target organ by the toxicity of matrine.
- Southern Medical University China (People's Republic of)
- Nanfang Hospital China (People's Republic of)
Male, Brain, Lethal Dose 50, Mice, Alkaloids, Toxicity Tests, Acute, Animals, Female, Matrines, Quinolizines
Male, Brain, Lethal Dose 50, Mice, Alkaloids, Toxicity Tests, Acute, Animals, Female, Matrines, Quinolizines
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