To describe the clinical and pathomorphological features of meibomian carcinoma (MC) diagnosed in a Simmental cow.A 7-year-old Simmental cow was admitted to the Veterinary Surgery Clinics of Faculty of Veterinary Medicine, University of Kafkas, Kars, Turkey. The signalment and anatomical distribution were summarized and focused on pathomorphological description.Macroscopically, a papillary mass, 5 × 3.5 × 7 cm in size, arising from the left lower eyelid with local spread to the upper eyelid and covering the entire globe was observed. The mass was ulcerated and hemorrhagic and applied pressure to the globe. Following sedation and local anesthesia, the mass and globe were excised. Histopathological examination revealed an MC.The diagnosis of MC is infrequent in veterinary literature. Complete surgical excision could be curative and histopathology is crucial for the diagnosis of MC occurring in animals.