129 patients with abdominal sepsis were divided in two groups. Patients of the 1st group (n=68) were treated according to the accepted standard. Patients of the 2nd group received the same treatment, but after germ translocation to the abdominal cavity and blood, immunoglobulin blood titer detection, drugs were administered through the cannulated umbilical vein straight to the portal system. Blood samples from ulnar and portal veins and microbiological samples from gut lumen showed similar results in patients with sepsis, proving the phenomenon of bacterial translocation. Histological analysis of liver biopsy demonstrated affection of both hepatocites and reticuloendothelial system of the liver by sepsis. The use of intraportal drug administration decreased mortality from 27.9% (1st group) to 16.3% (2nd group).