[Combined cycloferon treatment of tuberculosis in patients infected with HIV].

A K, Ivanov; T V, Sologub; A M, Panteleev; D S, Sukhanov; M G, Romantsov; A L, Kovalenko

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Экспериментальная и ...arrow_drop_down

Экспериментальная и клиническая фармакология

Article . 2010

Data sources: Europe PubMed Central

[Combined cycloferon treatment of tuberculosis in patients infected with HIV].

descriptionPublicationkeyboard_double_arrow_right Article 26 Oct 2010 Russian Journal:Eksperimental'naia i klinicheskaia farmakologiia, volume 73 (issn: 0869-2092,

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Authors: A K, Ivanov; T V, Sologub; A M, Panteleev; D S, Sukhanov; M G, Romantsov; A L, Kovalenko;

pmid: 20821978

[Combined cycloferon treatment of tuberculosis in patients infected with HIV].

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Abstract

Outcome of treatment of 102 patients co-infected with HIV and tuberculosis hospitalized at Second Municipal Tuberculosis Hospital (St. Petersburg) is analyzed. The median period of follow up was 8 weeks. In order to select the optimum treatment scheme, all patients were divided into three groups (I-III). Group I (51 patients) received, in addition to antituberculosis medications, cycloferon 600 mg tablets on alternate days. Group II (16 patients) received alpha and gamma interferons (Interal injection, 3 MU and Ingaron injection, 500,000 on alternate days) in combination with antituberculosis medications. Control group III (35 patients) received antituberculosis treatment plus placebo. Assessment of the outcome of TB treatment upon 8 weeks of follow up showed a remarkable improvement of clinical and immunological conditions in the patients who received interferons and cycloferon.

Keywords

Adult, Male, Immunity, Cellular, Interferon Inducers, Adolescent, Interferon-alpha, HIV Infections, Middle Aged, Interferon-gamma, Young Adult, Acridines, Humans, Female, Tuberculosis, Pulmonary

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