INTRODUCTION Platelets express junction proteins that are known to regulate cell-cell adhesion, barrier formation and communication in tissue forming cells. Previous research has shown that the gap junction proteins expressed by platelets regulate platelet activation in an αIIbβ3-dependent manner.1 Also, platelet activation processes are negatively regulated by endothelial cell-selective adhesion molecule (ESAM)2 and junctional adhesion molecule A (JAM-A)3, proteins that are part of the tight junctions (TJ) of endothelial cells. However, the role of zonula occludens 2 (ZO-2) -an intracellular component of the endothelial TJs- in the formation of inter-platelet contacts has not yet been described.