Powered by OpenAIRE graph
Found an issue? Give us feedback
addClaim

DECOS and SCG Basis for an Occupational Standard Isopropyl acetate

Authors: Stouten, H.;

DECOS and SCG Basis for an Occupational Standard Isopropyl acetate

Abstract

Isopropyl acetate is a colourless liquid with a fruity odour. It is soluble in water andacetone and miscible with alcohol and ether. Its vapour is heavier than air. Methods for personal air sampling are available. No data were available on the kinetics of isopropyl acetate. It can be expected that it will hydrolyse to acetic acid and isopropanol in the liver and the respiratory tract. Human data on effects are limited to old data concerning irritation. From lethality data following single exposure to animals, it can be seen that isopropyl acetate is hardly toxic via the various exposure routes. No experimental animal studies were allocated regarding effects following repeated exposure. Isopropyl acetate was negative in most genotoxic test systems, but was a weak inducer of aneuploidy. Based on the few existing data, the critical effect of occupational exposure to isopropyl acetate is irritation.

Isopropylacetat är en färglös vätska med fruktig doft. Den är löslig i vatten och aceton och blandbar med alkohol och eter. Ångorna är tyngre än luft. Det finns metoder för personburen provtagning. Det finns inga data avseende isopropylacetats kinetik. Man kan förmoda att den hydrolyseras till ättiksyra och isopropanol i lever och andningsorgan. Data över effekter på människa är begränsade till äldre data avseende irritation. Från letalitetsdata efter engångsexponering av försöksdjur kan man se att isopropanol knappast är toxiskt oavsett exponeringsväg. Det finns inga data avseende långtidsexponering av djur. Isopropylcetat var negativ i de flesta genotoxiska testsystem men gav en svag induktion av aneuploidi. Baserat på de få existerande data är den kritiska effekten vid yrkesmässig exponering irritation.

Countries
Sweden, Netherlands
  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Upload OA version
Are you the author of this publication? Upload your Open Access version to Zenodo!
It’s fast and easy, just two clicks!