Dental and/or periodontal diseases are an important clinical and social problem in patients with hemorrhagic diathesis. The possibility to overcome it successfully depends on the type of hemorrhagic disease and on the organization of hematological and odontostomatological centres: in fact, the best results in the surgery of these patients are obtained through the balanced combination of general and local treatments. The right diagnosis of coagulopathy is the first important goal: it can be obtained through the screening tests of hemostasis and, when necessary, through additional tests. Therapeutic protocols are available for each congenital or acquired hemorrhagic diathesis to prepare the patient for surgery; by so doing the risk of hemorrhagic complications is negligible. A better homogeneity in the approach to these patients in the different centres is highly desirable: the present review can offer a contribute in this respect.