Identification of neuropeptide Y-like conopeptides from the venom of Conus betulinus.
Copyright policy )Identification of neuropeptide Y-like conopeptides from the venom of Conus betulinus.
Neuropeptide Y (NPY) is a ubiquitous endocrine neuropeptide found in vertebrate and invertebrate. In our present work, two NPY-like exocrine conopeptides (designated as cono-NPYs) were first identified in the venom of cone snails. Both cono-NPYs showed sequence characteristics of invertebrate NPYs, suggesting that some exocrine venom peptides are probably evolved from the preexisting endocrine peptides during the evolution of cone snails.
- Tongji University China (People's Republic of)
Behavior, Animal, Dose-Response Relationship, Drug, Sequence Homology, Amino Acid, Molecular Sequence Data, Conus Snail, Mollusk Venoms, Hyperkinesis, Peptide Fragments, Evolution, Molecular, Molecular Weight, Mice, Animals, Neuropeptide Y, Amino Acid Sequence, Chromatography, High Pressure Liquid, Injections, Intraventricular
Behavior, Animal, Dose-Response Relationship, Drug, Sequence Homology, Amino Acid, Molecular Sequence Data, Conus Snail, Mollusk Venoms, Hyperkinesis, Peptide Fragments, Evolution, Molecular, Molecular Weight, Mice, Animals, Neuropeptide Y, Amino Acid Sequence, Chromatography, High Pressure Liquid, Injections, Intraventricular
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