[Gastroprotective properties of mexidol and hypoxen].

V E, Novikov; N O, Kriukova; A S, Novikov

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Экспериментальная и ...arrow_drop_down

Экспериментальная и клиническая фармакология

Article . 2010

Data sources: Europe PubMed Central

[Gastroprotective properties of mexidol and hypoxen].

descriptionPublicationkeyboard_double_arrow_right Article 20 Jul 2010 Russian Journal:Eksperimental'naia i klinicheskaia farmakologiia, volume 73 (issn: 0869-2092,

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Authors: V E, Novikov; N O, Kriukova; A S, Novikov;

pmid: 20597364

[Gastroprotective properties of mexidol and hypoxen].

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Abstract

Experimental damage in the stomach mucosa of test rats was modeled by acetylsalicylic acid (aspirin-induced ulcerogenesis). The number of ulcers and the total area of erosive injury in the mucous membrane were studied. Prophylactic treatment with mexidol and hypoxen in a daily dose of 50 mg/kg reduces the aspirin-induced damage of stomach mucosa. The gastroprotective properties of drugs are probably related to their antioxidant and antihypoxant effects.

Keywords

Aspirin, Gastric Mucosa, Phenyl Ethers, Anti-Inflammatory Agents, Non-Steroidal, Picolines, Animals, Stomach Ulcer, Antioxidants, Rats

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