HCV NS5B polymerase inhibitors.
Copyright policy )HCV NS5B polymerase inhibitors.
In the past decade, intensive efforts have focused on the discovery of both nucleos(t)ide and non-nucleoside inhibitors of the HCV NS5B polymerase. These efforts have resulted in several promising agents advancing in clinical development. This review traces the history of optimization of the chemical series that have led to the development of clinical candidates, and summarizes recent developments in the field, with emphasis on clinical efficacy and impact for future combination studies.
Animals, Humans, Hepacivirus, Enzyme Inhibitors, Hepatitis C, Chronic, Viral Nonstructural Proteins, RNA-Dependent RNA Polymerase, Antiviral Agents, Nucleic Acid Synthesis Inhibitors
Animals, Humans, Hepacivirus, Enzyme Inhibitors, Hepatitis C, Chronic, Viral Nonstructural Proteins, RNA-Dependent RNA Polymerase, Antiviral Agents, Nucleic Acid Synthesis Inhibitors
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).40 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!