The influence of domestic preparation "Cytoflavin" on the course of total intravenous anesthesia was studied in operations of mean duration in 30 patients. It was found that cytoflavin did not influence the need of anesthetic and narcotic analgetic, had cardioprotective effect and stabilized the hemodynamic parameters, the intraoperative frequency of critical incidents became 1.8-2.3 times less (p = 0.028), increasing safety of anesthesia, positively influenced the course of the postanesthetic rehabilitation, made the period of recovery 2 times shorter and the terms of extubation, orientation and readiness of the patient to transportation 1.6 times shorter.