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Estimating Optimal Dynamic Regimes: Correcting Bias under the Null: [Optimal dynamic regimes: bias correction].

Authors: Erica E M, Moodie; Thomas S, Richardson;

Estimating Optimal Dynamic Regimes: Correcting Bias under the Null: [Optimal dynamic regimes: bias correction].

Abstract

A dynamic regime provides a sequence of treatments that are tailored to patient-specific characteristics and outcomes. In 2004 James Robins proposed g-estimation using structural nested mean models for making inference about the optimal dynamic regime in a multi-interval trial. The method provides clear advantages over traditional parametric approaches. Robins' g-estimation method always yields consistent estimators, but these can be asymptotically biased under a given structural nested mean model for certain longitudinal distributions of the treatments and covariates, termed exceptional laws. In fact, under the null hypothesis of no treatment effect, every distribution constitutes an exceptional law under structural nested mean models which allow for interaction of current treatment with past treatments or covariates. This paper provides an explanation of exceptional laws and describes a new approach to g-estimation which we call Zeroing Instead of Plugging In (ZIPI). ZIPI provides nearly identical estimators to recursive g-estimators at non-exceptional laws while providing substantial reduction in the bias at an exceptional law when decision rule parameters are not shared across intervals.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
41
Top 10%
Top 10%
Average
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