The quality of a treatment is strictly connected to research and technological development: to carry out competitive research, investments in advanced technologies are compulsory. To invest in research and new technologies for the diagnosis and the treatment of neoplasies at first level is compulsory as well and it also represents the most effective method to save resources. The AWR (wide area Romagna) is an health care network which is now treating approx. 9,000 cancer patients a year in a regional population of 1,095,205 residents in the provinces of Forli-Cesena, Ravenna and Rimini. I.R.S.T (The Cancer Institute of Romagna) is the "nucleus" of the oncologic network: it works as a Hub for some highly specialized activities and as a Spoke for other activities on behalf of the Local Health Authorities. I.R.S.T.'s Mission is focused on Translational Research, representing a structure fully integrated within the Regional Health System. In agreement with the AVR's Local Health Authorities and on their behalf I.R.S.T. manages all oncological research and clinical trials, in addition to facilitating innovative trials, which require particular organizational structures and technologies that are not generally available in the oncologic network.