Hemolytic disease is the result of red blood cell antibody transfer from mother to fetus causing destruction of fetal red blood cells. Cell destruction is due to the antigen-antibody reaction. While Rh incompatibility has been rendered preventible, there are many other blood groups which can cause the same disease. The author prescribes a plan of management aimed at prevention of the disease, or at least minimization of its effects. He notes that there is no good method of evaluating ABO compatibility antenatally, hence the need for organization of medical manpower, laboratory facilities and technicians to combat the disease.