Diabetic macroangiopathy is severe complication for diabetes mellitus, and inflammatory cytokines induces various reactions for the formation of atherosclerosis in diabetes. In addition, recent reports indicate the accumulation of macrophages in the adipose tissue occurs in diabetes and these macrophages secret an inflammatory cytokines. It is also known macrophages produce most of circulating TNF-alpha. Accordingly, inflammatory cytokines, produced in adipose tissue, influence systemic inflammation possibly. Leukocyte-endothelial interactions are critical in the progression of inflammation and atherosclerosis. Recruitment of leukocytes to the sites of inflammation or atherosclerosis prone vasculature involves multistep complex cascades of adhesion events, which inflammatory cytokines induce. Inflammatory cytokines are not the only factor in diabetic macroangiopathy, however, it is certain that inflammation plays important role in diabetes and diabetic vascular complication.