Physiopathological, clinical, and epidemiological aspects of whooping cough, an acute highly contagious respiratory infection caused by Bordetella pertussis, are described. Different vaccination schedules are mentioned, since the vaccine was introduced, more than 40 years ago, until present; and the outbreaks occurred in Argentina during different periods. Moreover, the recrudescense of the disease observed in several countries during last years is highlighted, particularly in preschool children, and even more in adolescents, and young adults.