Immunocompromised patients with HBsAg a determinant mutants: comparison of HBsAg diagnostic assays.
Copyright policy )Immunocompromised patients with HBsAg a determinant mutants: comparison of HBsAg diagnostic assays.
Hepatitis B surface antigen (HBsAg) is considered the best marker for the diagnosis of hepatitis B virus (HBV) infection. Mutations of the s gene involving amino acid substitutions within the a determinant could affect the sensitivity of diagnostic tests. In the present study, HBsAg mutants were detected in 3 immunocompromised patients, previously found to be HBsAg negative and anti-HBs positive. All patients had high levels of HBV-DNA, whereas HBsAg tests gave discordant results. Immunosuppression can cause viral reactivation of occult HBV infection in these patients and favour the selection of HBsAg a determinant mutants.
Male, Hepatitis B virus, Mutation, Missense, P120L, Sensitivity and Specificity, Hepatitis B virus a determinant mutant; Hepatitis B surface antigen assay; Immuncompromised host; G145R; P120L; T123N, Immunocompromised Host, G145R, Virology, Humans, Hepatitis B Antibodies, Aged, Hepatitis B virus a determinant mutant, Immunoassay, Hepatitis B Surface Antigens, T123N, Immuncompromised host, Middle Aged, Hepatitis B, Hepatitis B surface antigen assay, Infectious Diseases, DNA, Viral, Female
Male, Hepatitis B virus, Mutation, Missense, P120L, Sensitivity and Specificity, Hepatitis B virus a determinant mutant; Hepatitis B surface antigen assay; Immuncompromised host; G145R; P120L; T123N, Immunocompromised Host, G145R, Virology, Humans, Hepatitis B Antibodies, Aged, Hepatitis B virus a determinant mutant, Immunoassay, Hepatitis B Surface Antigens, T123N, Immuncompromised host, Middle Aged, Hepatitis B, Hepatitis B surface antigen assay, Infectious Diseases, DNA, Viral, Female
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