Cytotoxic chemical constituents from the roots of Cimicifuga foetida. [corrected].
Copyright policy )Cytotoxic chemical constituents from the roots of Cimicifuga foetida. [corrected].
Seven new 9,19-cycloartane triterpene glycosides, 25-O-acetylcimigenol-3-O-[2'-O-(E)-2-butenoyl]-beta-d-xylopyranoside (1), 25-O-acetylcimigenol-3-O-[4'-O-(E)-2-butenoyl]-beta-d-xylopyranoside (2), 25-O-acetylcimigenol-3-O-[3'-O-acetyl]-beta-d-xylopyranoside (3), 25-O-acetylcimigenol-3-O-[4'-O-acetyl]-beta-d-xylopyranoside (4), 25-O-acetyl-12beta-acetoxycimigenol-3-O-beta-d-xylopyranoside (5), 3'-O-acetylactein (6), and 3'-O-acetyl-23-epi-26-deoxyactein (7), together with eight known compounds (8-15), were isolated from the roots of Cimicifuga fetida. Their structures were established by spectroscopic and chemical methods. Most of these compounds showed more selective and higher cytotoxicity against the human HepG2 cell line than against the MCF7, HT29, and MKN28 cell lines. Compounds 2, 3, and 7 exhibited significant cytotoxicity against HepG2 cells, with IC(50) values of 1.29, 0.71, and 1.41 microM, respectively.
- Chinese Academy of Sciences China (People's Republic of)
- Kunming Institute of Botany China (People's Republic of)
Cimicifuga, Molecular Structure, Stereoisomerism, Hep G2 Cells, Antineoplastic Agents, Phytogenic, Plant Roots, Triterpenes, Humans, Glycosides, Drug Screening Assays, Antitumor, HT29 Cells, Nuclear Magnetic Resonance, Biomolecular, Drugs, Chinese Herbal
Cimicifuga, Molecular Structure, Stereoisomerism, Hep G2 Cells, Antineoplastic Agents, Phytogenic, Plant Roots, Triterpenes, Humans, Glycosides, Drug Screening Assays, Antitumor, HT29 Cells, Nuclear Magnetic Resonance, Biomolecular, Drugs, Chinese Herbal
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