As the demand for energy is increasing day by day and the fossil fuels are getting depleted at a faster rate. Among the renewable energy sources, the use of solar or photovoltaic (PV) energy is increasing day by day due to freely available, pollution-free, low maintenance cost, reliable, and infinite. The efficiency of the PV system mainly depends on the solar irradiance and temperature. Especially, partial shading has negative effect on the PV system. Therefore, in the literature, many approach have been presented for this problem and one of them is PV array configurations. In this study, in order to examine the efficiency of PV array configurations, total cross tied (TCT), series parallel–total cross tied (SP-TCT), and bridged link–total cross tied (BL-TCT) configurations are carried out for 4×6 size of PV array under partial shading. The simulation of the PV array configurations was done for various shading patterns such as, short and narrow (SN), short and wide (SW), long and narrow (LN), long and wide (LW), and randomly distributed (RD) patterns. The results for each shading patterns were compared according to mismatch loss and fill factor. TCT has the best performance than the other configurations. Moreover, performance of the configurations are compared in terms of mismatch loss and fill factor. With reference to this, TCT has less mismatch loss and high fill factor by comparison with the others.