Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Recolector de Cienci...arrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
Docta Complutense
Doctoral thesis . 2014
Data sources: Docta Complutense
versions View all 4 versions
addClaim

This Research product is the result of merged Research products in OpenAIRE.

You have already added 0 works in your ORCID record related to the merged Research product.

Aplicación de fosfatos de calcio y fibronectina como tratamiento complementario en fracturas sobre hueso osteoporótico

Authors: Quintana Plaza, Javier;

Aplicación de fosfatos de calcio y fibronectina como tratamiento complementario en fracturas sobre hueso osteoporótico

Abstract

"INTRODUCCIÓN": El envejecimiento progresivo de la población ha generado un incremento en la incidencia de las fracturas osteoporóticas. Fracturas que asocian tasas de no unión de entre 2-10%, fracasos en la osteosíntesis 1-10% y tasas de reintervención 3-23%. Una de las posibles soluciones para el elevado número de complicaciones que presentan estas fracturas son los biomateriales, como la hidroxiapatita y la fibronectina. "OBJETIVO": Probar la eficacia de nuestro material, hidroxiapatita y fibronectina como tratamiento complementario en la fijación de fracturas osteoporóticas en un modelo experimental. "MATERIAL Y MÉTODO": 42 conejos hembras (White New Zealand) a los que previamente se les había inducido osteoporosis mediante un protocolo con corticoides, se les realizó un brocado en el cóndilo femoral lateral de ambas patas traseras. En una se aplicaba hidroxiapatita o hidroxiapatita con fibronectina siendo la contralateral el control, y posteriormente se implantaba un tornillo. Se analizaron las muestras mediante un análisis histológico y por imagen a 24 horas, 48 horas y 5 días. "DISCUSIÓN": La fractura osteoporótica es un problema creciente en nuestros días. La osteosíntesis supone un reto para el cirujano por tratarse de un hueso con una densidad mineral y una arquitectura alterada. En nuestro estudio objetivamos una mejora en los parámetros de la morfología del hueso trabecular, en el grupo de muestras con proteína frente al resto. El análisis histológico de los especímenes muestra un incremento de la celularidad no inflamatoria y del tejido conectivo en las muestras con proteína desde las primeras 24 horas. "CONCLUSION": A través de la fibronectina combinada con hidroxiapatita podemos modelar el proceso de regeneración ósea y conseguir una consolidación más temprana, reduciendo el número de complicaciones que causan este tipo de fracturas. [ABSTRACT]"BACKGROUND": The gradual aging of the population results in increased incidence of osteoporotic bone fractures. In a good quality bone, the fixation with the usual methods is enough, but not in osteoporotic bone. Consolidation delays and other complications are common. Possible solutions are biomaterials like hydroxiapatite or fibronectin. "OBJECTIVE": To test our material, hydroxyapatite plus fibronectine, as a complementary treatment for osteoporotic fractures in an animal model." METHODS": Osteoporosis was induced in forty two White New Zealand female rabbits based on models already known. Defects were created in both femurs through a lateral approach to the femoral condyle. One femur was supplied with hydroxiapatite or hidroxiapatite plus fibronectin and a screw. Contralateral femur was left only with the screw (control group). Samples were harvested at 24 h, 48h and 5 days in order to provide information about the effect of augmentation through a histological and imaging analysis. "DISCUSSION": The osteoporotic fracture is a growing problem nowadays. Osteosynthesis is a challenge for the surgeon because it is a bone with a lower mineral density and altered architecture. In our study, we identified an improvement in the parameters that describe trabecular bone in the group with protein. Histological analysis of the specimens showed no increased inflammatory cells and connective tissue in the samples with protein from the first 24 hours. "CONCLUSIONS": Through hydroxyapatite plus fibronectin we can model the process of bone regeneration and get an earlier consolidation, reducing the number of complications that cause osteoporotic fractures

Related Organizations
Keywords

fibronectina, fracture, fibronectin, Cirugía, fractura, 616.71-001.5(043.2), osteoporosis, 3213 Cirugía

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green