This conference addresses the gap between the research culture with which Digital Humanists are equipped via their disciplinary backgrounds and the research culture they foster in this field. Why does experimentation play a crucial role in Digital Humanities? How does it contribute to define the relationship between method and research questions? Can we identify barriers which currently prevent Digital Humanities from developing their full potential, leaving little room for iteration, comparison or failure? The conference itself is conceived as an experimental set-up with labs, data experiments and round tables.