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Cancer-specific survival by stage of bladder cancer and factors collected by Mallorca Cancer Registry associated to survival

Authors: Ripoll Amengual, Joana; Ramos Monserrat, Maria; Montaño, Juan José; Pons De Ves, Jaime; Ameijide, Alberto; Franch, Paula; Amengual Tomas, Jeronima Maria;

Cancer-specific survival by stage of bladder cancer and factors collected by Mallorca Cancer Registry associated to survival

Abstract

Information about survival by stage in bladder cancer is scarce, as well as about survival of non-invasive bladder cancer. The aims of this study are: 1) to find out the distribution of bladder cancer by stage; 2) to determine cancer-specific survival by stage of bladder cancer; 3) to identify factors that explain and predict the likelihood of survival and the risk of dying from these cancers. Incident bladder cancer cases diagnosed between 2006 and 2011 were identified through the Mallorca Cancer Registry. cases with code C67 according to the ICD-O 3rd edition with any behaviour and any histology, except lymphomas and small cell carcinomas. Cases identified exclusively through the death certificate were excluded. We collected the following data: sex; age; date and method of diagnosis; histology according to the ICD-O 3rd edition; T, N, M and stage at the time of diagnosis; and date of follow-up or death. End point of follow-up was 31 December 2015. Multiple imputation (MI) was performed to estimate cases with unknown stage. Cases with benign or indeterminate behaviour were excluded for the survival analysis. Actuarial and Kaplan-Meier methods and Cox regression models were used for survival analysis. One thousand nine hundred fourteen cases were identified. 14% were women and 65.4% were 65 years or older. 3.9% had no stage (benign or undetermined behaviour) and 11.5% had unknown stage. After MI, 37.5% were in stage Ta (non-invasive papillary carcinoma), 3.2% in stage Tis (carcinoma in situ), 34.3% in stage I, 11.7% in Stage II, 4.3% in stage III, and 9.0% in stage IV. Survival was 76% at 5 years. Survival by stage: 98% at stage Ta, 90% at stage Tis, 85% at stage I, 45% at stage II, 35% at stage III, and 7% at stage IV. The Cox model showed that age, histology, and stage, but not sex, were associated with survival. Bladder cancer survival vary greatly with stage, among both non-invasive and invasive cases. The percentage of non-invasive cancers is high. Stage, age, and histology are associated to survival.

Country
Spain
Keywords

Adult, Male, Factores de Edad, Adolescent, Urinary Bladder, Anciano, España, Kaplan-Meier Estimate, Estudios Retrospectivos, Sistema de Registros, Risk Assessment, Carcinoma de Células Transicionales, Young Adult, Risk Factors, Estimación de Kaplan-Meier, Humans, Tasa de Supervivencia, Registries, Masculino, Adolescente, Aged, Neoplasm Staging, Retrospective Studies, Factores de Riesgo, Carcinoma, Transitional Cell, Persona de Mediana Edad, Adulto, Vejiga Urinaria, Age Factors, Femenino, Adulto Joven, Middle Aged, Carcinoma, Papillary, Estadificación de Neoplasias, Neoplasias de la Vejiga Urinaria, Humanos, Survival Rate, Urinary Bladder Neoplasms, Spain, Carcinoma Papilar, Estudios de Seguimiento, Female, Carcinoma in Situ, Medición de Riesgo, Follow-Up Studies

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
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Cancer Research