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Correlación entre glucosa salival con la glucosa de ayuno, la hemoglobina glicada y el péptido C en personas con diabetes mellitus tipo 2

Authors: Motta Arevalo, Esthefany Milagros; Chipayo Ramirez, Cynthia; Palomino Ccorimanya, Carmen Rosa;

Correlación entre glucosa salival con la glucosa de ayuno, la hemoglobina glicada y el péptido C en personas con diabetes mellitus tipo 2

Abstract

Objetivo: Determinar la correlación entre la glucosa salival y marcadores de disfunción de célula beta en pacientes con Diabetes Mellitus tipo 2 (DM2). Materiales y métodos: Estudio transversal llevado a cabo en el Centro de Investigación en Diabetes, Obesidad y Nutrición (CIDON) en Lima, Perú durante el año 2021. Se categorizó en buen control metabólico (HbA1c<7%) y mal control metabólico (HbA1c≥7%). Se midió la glucosa basal, HbA1c y el péptido C en sangre. La glucosa salival se midió con el método glucosa-oxidasa. La correlación de Spearman fue usada para determinar la asociación entre la glucosa salival y los marcadores de disfunción de célula beta. Resultados: Participaron un total de 142 personas con DM2. La concentración de glucosa salival fue significativamente más elevada en DM2 con mal control metabólico (p<0.01). Se observó una correlación positiva débil significativa entre la glucosa salival y la glucosa basal (r=0.23, p=0.04) y HbA1c (r=0.26, p=0.02) en DM2 con mal control metabólico y una correlación negativa insignificante (r=-0.08; p=0.47) con el péptido C. Conclusiones: La glucosa salival presenta una asociación significativa y positiva con la glucosa en sangre y la HbA1c, pero no con el péptido C en personas con DM2 con mal control metabólico. Sin embargo, hay muchos factores que deben ser considerados y analizados más a fondo para determinar su posible uso.

Objective: To determine the correlation between salivary glucose and markers of beta cell dysfunction in patients with Type 2 Diabetes (T2D). Materials and methods: Cross-sectional study carried out at the Diabetes, Obesity and Nutrition Research Center (CIDON) in Lima, Peru during 2021. Patients were categorized into good metabolic control (HbA1c<7%) and poor metabolic control (HbA1c≥7%). Basal glucose, HbA1c and blood C-peptide were measured. Salivary glucose was measured with the glucose oxidase method. Spearman correlation was used to determine the association between salivary glucose and markers of beta-cell dysfunction. Results: A total of 142 persons with T2DM participated. Salivary glucose concentration was significantly higher in T2DM with poor metabolic control (p<0.01). A significant weak positive correlation was observed between salivary glucose and basal glucose (r=0.23, p=0.04) and HbA1c (r=0.26, p=0.02) in T2DM with poor metabolic control and an insignificant negative correlation (r=-0.08; p=0.47) with C-peptide. Conclusions: Salivary glucose has a significant and positive association with blood glucose and HbA1c, but not with C-peptide in people with DM2 with poor metabolic control. However, there are many factors that must be considered and further analyzed to determine their potential use.

Country
Peru
Keywords

http://purl.org/pe-repo/ocde/ford#2.06.02, Glucosa, Diabetes Mellitus Tipo 2, Hemoglobina A Glicada, Péptido C, http://purl.org/pe-repo/ocde/ford#3.02.18, Saliva, http://purl.org/pe-repo/ocde/ford#1.06.01, http://purl.org/pe-repo/ocde/ford#3.02.06, http://purl.org/pe-repo/ocde/ford#1.06.03

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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