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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Padua Thesis and Dis...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Padua Thesis and Dissertation Archive
Bachelor thesis
Data sources: Padua Thesis and Dissertation Archive
Claim

Discovery and characterization of nanobodies against the transcriptional repressor LexA of Pseudomonas aeruginosa

descriptionPublicationkeyboard_double_arrow_right Bachelor thesis Italy
Authors: PEDRONI, GIULIA#idabnull;

handle: 20.500.12608/51283

Discovery and characterization of nanobodies against the transcriptional repressor LexA of Pseudomonas aeruginosa

Abstract

Discovery and characterization of nanobodies against LexA of Pseudomonas aeruginosa. LexA is a transcriptional repressor that undergoes an autocatalytic cleavage induced by the protein RecA. This mechanism allows the derepression of those genes that are expressed in response to DNA damage. Their activity is highly mutagenic and for this reason can cause antibiotic resistance appearance. The main goal of this thesis is to characterize nanobodies directed against LexA to inhibit its autocatalytic cleavage, involved in genetic variability occurence, in order to reduce the induction of sos response.

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Italy
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    popularity
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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