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¿Por qué un banco público de células madre de sangre de cordon umbilical en Colombia?

Authors: Henao Pérez, Julieta; Pacheco Pinedo, Eugenia Cristina; Arboleda Toro, Germán David; Gómez Aristizabal, Alejandro; Restrepo Múnera, Luz Marina;

¿Por qué un banco público de células madre de sangre de cordon umbilical en Colombia?

Abstract

RESUMEN: El trasplante de células madres hematopoyéticas (CMH) obtenidas de médula ósea (MO) se ha convertido en el tratamiento de elección para diferentes desórdenes hematológicos. Pero éste presenta dificultades, que pueden mejorarse con el uso de de sangre de cordón umbilical (SCU), fuente importante de CMH de rápida disponibilidad, fácil obtención, inofensivo para el donante, menor restricción de histocompatibilidad (HLA), menor rechazo y menor transmisión de enfermedades infecciosas. Además, poseen potenciales de expansión y proliferación más altos que los de MO. Un banco público de SCU permite que las células estén disponibles para quien las pueda necesitar. La tipificación previa, permite fácilmente donaciones no relacionadas, pero compatibles. La carencia de redes de donación de MO en Colombia y la gran cantidad de nacimientos anuales, generan la necesidad y oportunidad de crear un banco público de SCU que aumente las probabilidades para receptores de minorías étnicas.

ABSTRACT: Bone marrow hematopoietic stem cells (HSC) transplant has turned into the preferred treatment for different hematopoietical disorders. However it has difficulties that could be improved by using Umbilical Cord Blood (UCB). UCB is an important source of HSC that can be acquired fast, easily, without risk for the donor, with less histocompatibility (HLA) restriction, higher acceptance and less transmission of infective diseases. Furthermore, HSC from UCB have higher potential of expansion and proliferation than those from bone marrow. An UCB Public Bank has available cells for anyone who would need them. In addition, the previous hand tipification, simplifies not related compatible donations. The lacking of bone marrow donor networks in Colombia and the high amount of annual births creates the need and opportunity to set an UCB public bank that would improve the odds for possible receptors from ethnic minorities.

COL0027213

Country
Colombia
Keywords

Banco público de sangre de cordón umbilical, Células Madre, Public umbilical cord blood bank., Cordón Umbilical, Células madre, Sangre de cordón umbilical, Stem Cells, 610, Sangre Fetal, Human stem cells, Trasplante de Células Madre, Fetal Blood, Umbilical Cord, Umbilical cord blood, Blood Banks, Bancos de Sangre, Stem Cell Transplantation

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green