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Caracterización de anticuerpos monoclonales dirigidos contra la proteína de exportación nuclear (NEP) del virus de Influenza A H1N1

Authors: Navarro López, René Alejandro;

Caracterización de anticuerpos monoclonales dirigidos contra la proteína de exportación nuclear (NEP) del virus de Influenza A H1N1

Abstract

"Los virus de la influenza son responsables de causar epidemias anuales, por lo que se deben de buscar tratamientos dirigidos a puntos clave de su replicación y de proteínas altamente conservadas entre diferentes subtipos. La proteína de exporte nuclear (NEP) cumple con estas características con una alta identidad del 93.4% entre diferentes aislados. Su alta conservación no sorprende, pues cumple con diferentes roles durante la replicación viral además del exporte nuclear de los genomas virales; como reguladora de la transcripción y la replicación; reclutadora de las translocadoras F1F0–ATPasas para el plegamiento de la membrana en el sitio de gemación viral; inductora del estado antiviral; y como mediadora en el silenciamiento de los ARNm celulares."

Country
Mexico
Keywords

Biosensores, Biotecnología farmacéutica, Genomas virales, BIOLOGÍA Y QUÍMICA, Proteinas

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    popularity
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green