Fungi are present everywhere in indoor and outdoor environments. Trichophyton spp. are fungal species that known as tinea infections in various areas in humans and animals. Enilconazolum is used antifungal drug for the treatment of both superficial and deep infections caused by Trichophyton. Moreover, the therapeutic response may be slow, and thus inappropriate for treatment of patients with severe or rapidly progressive infections. Essential oils are one of the most promising groups of natural compounds for the development of safer antifungal agents. Many essential oils are only fungistatic and high concentrations are needed for fungicidal activity. To enhance the efficacy of essential oils, the combined use of different oils has been evaluated recently for synergistic effects. The combination of essential oils with synthetic antifungals will probably result in a more effective therapy. Antifungal agents were tested against fungal isolates using the agar diffusion method. We used the essential oil Monarda Didyma L. The results of the agar diffusion tests indicate that these essential oil is significantly potent against Trichophyton spp. MIC assay results exhibited strong inhibition of 9 mm in most of the experimental concentrations of 50 % and 1 % of agar diffusion test. The MIC synergism of the essential oil Monarda Didyma L. with enilconazolum were remarkably decreased and agar diffusion test exhibited inhibition of 20 – 30 mm sterile zone. The combination and synergism essential oils Monarda Didyma L. and enilconazolum may reduce the efficacious dose of enilconazolum and minimize the side - effects of enilconazolum.