The Treatise on Human Anatomy published by Edi.Ermes for the first time in 1975 has been for over 40 years the reference text for many young students devoted to Medicai Science We now release a new edition of the Treatise on Human Anatomy that, while maintaining the originai systemic and methodological approaches, faces some new challenges. Firstly, in the last ten years, Anatomy has been enriched with a large body of new data at the microscopie and ultramicroscopic level, and on the macroscopic and functional level of the living being, the latter mostly thanks to the progress of technologies in the field of diagnostic imaging. A second challenge stems from the training courses of the Degree in Medicine and Surgery providing an increasing interaction between clinical and basic disciplines, as demonstrated by the involvement of Anatomy teaching even in later years of the MD courses. Thus, this 1st English edition, based on the 5th original edition, is characterized by the functional, clinical and radiological approaches as well as by the exceptionally accurate and updated iconography. Examples of these innovations can be found in the reported in-depth studies of the Joint Biomechanics, in the description of the Locomotor System or in the Neuroscience approach in the description vf the Central Nervous System. A major innovative aspect of this edition is the web platform, Virtual Campus, containing complementary didactical material: i.e., interactive three-dimensional reconstructions of organs or regions of living subjects obtained through CT or MRI scans, videos and images of anatomical dissections on cadavers, videos and images of endoscopic anatomy on living subjects and more. Finally, as Edi.Ermes has completed the translation from Latin of the last "Nomenclatura Anatomica", the terminology has been updated in this edition; thus, the reader will find universally accepted terms and a common and international identifying language (for example, "Apparatus" has been replaced by the term "System" according to the later nomenclature). We express our heartfelt thanks to the Publisher, Raffaele Grandi and his staff, for having supported and shared the completion of this work with competence, enthusiasm and patient dedication. Moreover, in the perspective that this Treatise will successfully exceed the milestone of 50 years from its 1st Italian edition, we turn our thoughts to Italo and Franca Grandi, founders of Edi.Ermes, who would be very proud of this publication. Finally, we dedicate the work done to realize this edition to our Masters and to the students, both to those who will continue to spread, in the years to come, the passion for Human Anatomy and those who, understanding the relevance of this discipline, will make it a pillar in their Medical Profession.