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Multifractal analysis of DNA

Authors: Rifaat, Rasekh;

Multifractal analysis of DNA

Abstract

This thesis presents two techniques for analyzing DNA using a multifractal methodology. The DNA analysis presented in the thesis is motivated by the intriguin possibility of identifying biological functionality using information contained within the DNA sequence. In addition, the analysis may give insight into the nature of DNA complexity, and provide guidelines for the selection of operating parameters such as the minimum DNA sequence length which can be analyzed. The first technique breaks a DNA sequence into four subsequences based on the individual constituent bases, and treats each of these as strange attractors from which the multifractal dimension may be estimated. Results show that the generated subsequences exhibit multifractal properties which can be localized to different positions along the sequences. A minimum window size of 256 bases, and a scaling range from 64 to 256 bases is needed for estimation of the multifractal measures. The second technique estimates the multifractal spectrum of DNA based on n-block entropies. The minimum window size was selected to be 1024 bases along with a scale range of one to three base pair sequence lengths. Experimental results show that DNA has a multifractal characteristic using this measure, and that the multifractality changes depending upon the position in a sequence. The phylogeny of organisms based on their multifractality was demonstrated with only two misclassifications, which may have other unresolved issues.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green