[Antiaggregant properties of new 1,3,4-thiadiazine derivatives].

T M, Vasil'eva; V A, Makarov; O N, Chupakhin; L P, Sidorova; N M, Perov; V L, Rusinov

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Экспериментальная и ...arrow_drop_down

Экспериментальная и клиническая фармакология

Article . 2009

Data sources: Europe PubMed Central

[Antiaggregant properties of new 1,3,4-thiadiazine derivatives].

descriptionPublicationkeyboard_double_arrow_right Article 15 Dec 2009 Russian Journal:Eksperimental'naia i klinicheskaia farmakologiia, volume 72 (issn: 0869-2092,

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Authors: T M, Vasil'eva; V A, Makarov; O N, Chupakhin; L P, Sidorova; N M, Perov; V L, Rusinov;

pmid: 19928572

[Antiaggregant properties of new 1,3,4-thiadiazine derivatives].

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Abstract

A series of new 1,3,4-thiadiazine derivatives have been synthesized and their effect on the human platelet aggregation in vitro has been studied. All the tested substances inhibit the human platelet aggregation induced by ADP and arachidonic acid in a broad concentration range. The most active 1,3,4-thiadiazines (L-19, L-28 and L-31) effectively inhibit platelet aggregation at concentrations within 0.01-1 mM.

Keywords

Adenosine Diphosphate, Blood Platelets, Arachidonic Acid, Dose-Response Relationship, Drug, Platelet Aggregation, Thiadiazines, Humans, Platelet Aggregation Inhibitors

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