[Clinical significance of some genetic polymorphisms of cytochrome P-450 subfamilies CYP2D, CYP2E and CYP3A--part II].

Anna, Wojtczak; Jadwiga, Skretkowicz

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Article . 2010

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[Clinical significance of some genetic polymorphisms of cytochrome P-450 subfamilies CYP2D, CYP2E and CYP3A--part II].

descriptionPublicationkeyboard_double_arrow_right Article 11 Jan 2010 Polish Journal:Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, volume 27 (issn: 1426-9686,

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Authors: Anna, Wojtczak; Jadwiga, Skretkowicz;

pmid: 19856888

[Clinical significance of some genetic polymorphisms of cytochrome P-450 subfamilies CYP2D, CYP2E and CYP3A--part II].

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Abstract

Polymorphism of drugs biotransformation is clinically significant from the point of view of the effectiveness and safety of pharmacotherapy and an increased risk of some illnesses. The paper presents molecular mechanisms and clinical implication of several genetic polymorphisms of cytochrome P-450 (CYP) xenobiotics metabolizing enzymes and genetic predisposition to the occurrence of some diseases.

Related Organizations

Medical University of Lodz
Poland

Keywords

Polymorphism, Genetic, Cytochrome P-450 Enzyme System, Humans, Genetic Predisposition to Disease, Xenobiotics

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