The induction of tumors in Rana temporaria with nitrosamines.
Copyright policy The induction of tumors in Rana temporaria with nitrosamines.
Dimethylnitrosamine (DMNA) and diethylnitrosamine (DENA) dissolved in tank water in a dose of 5 and 50 ppm, resp. induced tumors of liver (hepatocellular cancers and adenomas), and of hematopoietic system (hemocytoblastosis). DMNA induced neoplasms in 19 of 43 frogs (44.2%); the average latent period being 18.2 weeks, while DENA induced tumors in 41 of 94 animals (43.6%) within a mean latent period 19.7 weeks. Results of this investigation show the possibility to use anuran amphibians in shorttermed experiments in the study of nitrosocompounds carcinogenicity as well as a biological indicator for environmental pollution.
Adenoma, Carcinoma, Hepatocellular, Nitrosamines, Time Factors, Hematopoietic System, Liver Neoplasms, Rana temporaria, Neoplasms, Experimental, Dimethylnitrosamine, Animals, Diethylnitrosamine, Anura
Adenoma, Carcinoma, Hepatocellular, Nitrosamines, Time Factors, Hematopoietic System, Liver Neoplasms, Rana temporaria, Neoplasms, Experimental, Dimethylnitrosamine, Animals, Diethylnitrosamine, Anura
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