[Incretin and bone].
Copyright policy )[Incretin and bone].
Gastrointestinal hormones including gastric inhibitory polypeptide (GIP) and glucagon-like peptide (GLP) -1 are incretin, which are secreted immediately after meal ingestion and stimulate insulin secretion from pancreatic beta-cells. Characterization of extra-pancreatic GIP and GLP-1 receptors has revealed that these hormones regulate bone turnover. GIP intermittently stimulates osteoblasts and GLP-1 suppresses osteoclasts through a calcitonin-dependent pathway to increase the bone volume.
- Akita University Japan
Calcitonin, Osteoblasts, Osteoclasts, Gastric Inhibitory Polypeptide, Incretins, Bone and Bones, Glucagon-Like Peptide-1 Receptor, Receptors, Gastrointestinal Hormone, Eating, Glucagon-Like Peptide 1, Insulin-Secreting Cells, Insulin Secretion, Receptors, Glucagon, Animals, Humans, Insulin
Calcitonin, Osteoblasts, Osteoclasts, Gastric Inhibitory Polypeptide, Incretins, Bone and Bones, Glucagon-Like Peptide-1 Receptor, Receptors, Gastrointestinal Hormone, Eating, Glucagon-Like Peptide 1, Insulin-Secreting Cells, Insulin Secretion, Receptors, Glucagon, Animals, Humans, Insulin
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