Synthesis of 1,2,4-triazine derivatives as potential anti-anxiety and anti-inflammatory agents.

descriptionPublicationkeyboard_double_arrow_right Article 08 Sep 2009 English Journal:Acta poloniae pharmaceutica, volume 66 (issn: 0001-6837,

Authors: Pooja, Mullick; Suroor A, Khan; Tauseef, Begum; Surajpal, Verma; Darpan, Kaushik; Ozair, Alam;

pmid: 19702169

Synthesis of 1,2,4-triazine derivatives as potential anti-anxiety and anti-inflammatory agents.

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Abstract

A series of 1,2,4-triazine derivatives Va (1-24) and Vb (1-24) were synthesized and evaluated for their anti-anxiety and anti-inflammatory activities. The structures of the synthesized compounds were confirmed on the basis of their spectral data. Many of the triazine compounds were found to possess good activity. Especially, compounds bearing the sulfur atom showed better activity than those bearing the oxygen atom.

Related Organizations

Hamdard University
Pakistan

Keywords

Structure-Activity Relationship, Anti-Anxiety Agents, Triazines, Anti-Inflammatory Agents, Hydrazones, Animals, Rats

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