Regular physical activity is meant to be one of the most important nonpharmacological tools in reducing overall cardiometabolic risk since it significantly regulates body weight, blood pressure, blood glucose and lipid levels, and it also improves strength flexibility and quality of life and reduces stress. However, it should be individually prescribed, according to the patient's previous health status, individual desires and goals. Previous examinations (exercise stress testing, searching for vascular and neurological complications) are highly recommended in order to avoid potential risks (cardiovascular, microvascular, macrovascular, musculosceletal) ones. It should be strictly defined according to the type (aerobic vs. anaerobic activities), frequency (at least 3-5 times a week), duration (at least 20 to 60 minutes per session), intensity (55-90% of maximal heart rate) and energy expenditure (700-2000 kcal per week). It is highly recommended to be performed under supervision, at least at the beginning of the programme. Regular physical activity should become a part of everybody's lifestyle, especially in people at a high cardiovascular risk, in order to prevent the disease, as well as in those with already diagnosed cardiovascular disease, to prevent its complications.