A case of childhood acute myeloid leukemia AML (M5) with a neocentric chromosome neo(1)(qter-->q23 approximately 24::q23 approximately 24-->q43-->neo-->q43-->qter) and tetrasomy of chromosomes 8 and 21.
Copyright policy )A case of childhood acute myeloid leukemia AML (M5) with a neocentric chromosome neo(1)(qter-->q23 approximately 24::q23 approximately 24-->q43-->neo-->q43-->qter) and tetrasomy of chromosomes 8 and 21.
Hyperdiploidy is rarely observed in childhood acute myeloid leukemia (AML). Described here is the case of a 2(1/2)-year-old girl with AML-M5 and 51 chromosomes characterized by double tetrasomy of chromosomes 8 and 21 and also a neocentric derivative chromosome neo(1)(qter-->q23 approximately 24::q23 approximately 24-->q43-->neo-->q43-->qter). Little is known about the prognostic significance of these chromosomal abnormalities in childhood AML. In the actual case, complete remission was achieved after chemotherapy, which continued for 7 months. No acquired neocentric chromosome 1 has been described previously, even though neocentromere formation has been reported for other chromosomes in neoplasms.
Chromosome Aberrations, Chromosomes, Human, Pair 21, Child, Preschool, Karyotyping, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Humans, Female, In Situ Hybridization, Fluorescence, Chromosomes, Human, Pair 8
Chromosome Aberrations, Chromosomes, Human, Pair 21, Child, Preschool, Karyotyping, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Humans, Female, In Situ Hybridization, Fluorescence, Chromosomes, Human, Pair 8
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