Enantio-oligodeoxyribonucleotides.
Copyright policy )Enantio-oligodeoxyribonucleotides.
As a sugar-modified oligonucleotide, a hexamer of 9-(2-deoxy-beta-L-erythro-pentafuranosyl)-9H-purin-6-amine, [L-(dAp)5dA], was synthesized by triester method. The L-hexamer was resistant to bovine spleen phosphodiesterase. UV absorption studies indicated that L-hexamer formed a complex with poly U but not with poly dT at 0 degrees C. It was assumed that enantio-DNA's possese the ability to distinguish complementary RNA from DNA.
- University of Tokyo Japan
Poly U, Molecular Structure, Oligodeoxyribonucleotides, Poly T, Adenine Nucleotides, Phosphoric Diester Hydrolases, Animals, Cattle, Spectrophotometry, Ultraviolet, Spleen
Poly U, Molecular Structure, Oligodeoxyribonucleotides, Poly T, Adenine Nucleotides, Phosphoric Diester Hydrolases, Animals, Cattle, Spectrophotometry, Ultraviolet, Spleen
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