[Carcinogenic hazard of chloroform and other drinking water chlorination by-products].

I A, Chernichenko; N V, Balenko; O N, Litvichenko

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Hygiene and Sanitati...arrow_drop_down

Hygiene and Sanitation

Article . 2009

Data sources: Europe PubMed Central

[Carcinogenic hazard of chloroform and other drinking water chlorination by-products].

descriptionPublicationkeyboard_double_arrow_right Article 15 Sep 2009 Russian Journal:Gigiena i sanitariia (issn: 0016-9900,

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Authors: I A, Chernichenko; N V, Balenko; O N, Litvichenko;

pmid: 19642551

[Carcinogenic hazard of chloroform and other drinking water chlorination by-products].

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Abstract

The paper presents the results of studying the carcinogenic effect of chloroform and its combination with carbon tetrachloride, 1,2-dichloroethane, trichloroethylene during chronic oral administration to F1(CBAxC57Bl6) mice. There is a relationship between the manifestation of carcinogenesis to the dose of chloroform and a combination of chemicals, as well as its enhancement upon exposure to the combination as compared with acute administration of chloroform. Exposure to a combination of substances at the level of their maximum permissible concentrations does not affect carcinogenesis. The possible mechanisms of the specific features of carcinogenesis in this experiment are discussed.

Keywords

Male, Carcinogenicity Tests, Neoplasms, Experimental, Trichloroethylene, Mice, Inbred C57BL, Mice, Mice, Inbred CBA, Animals, Female, Chloroform, Ethylene Dichlorides, Carbon Tetrachloride, Water Pollutants, Chemical

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