Some scientific and scientific-industrial radioecological problems of Chernobyl NPP Exclusion Zone are considered. These problems are demanding its solution or development of already obtaining results for adequate understanding and planning of conducted researches as well as for decision support of activities directed to minimization of the accident consequences. Following problems are discussed: an estimation of radiological significance of natural and technogenic objects of the Zone, long-term dynamics of radioecological processes, autorehabilitation processes of the Zone ecosystems, complex estimation of the influence of the Zone technogenic objects to radioecological state of ecosystems, radioecology of urban ecosystems (by the example of former town Pripyat) and problems of rehabilitation of abandoned areas.