Electroodontometry was used to examine the pain threshold and sensation threshold in patients with depersonalization, endogenous depression and in mentally healthy test subjects. The strongest differences in the thresholds were found on the anterior teeth. The patients with depersonalization manifested a considerable rise of the sensation threshold and to an ever greater degree of the pain threshold. In patients suffering from endogenous depression, both thresholds were decreased and coincided almost completely. It is likely that this fact is associated with a relatively higher incidence of the painful syndrome in patients suffering from depression.