The study aims to describe pericarditis in HIV-infected patients in epidemiological, clinical and paraclinical aspects.In a prospective study from april 2005 to march 2006, 49 patients from 2 medical centers, were recruited grounded on clinic, echocardiographic evaluation et and the positivity of the HIV-serology. Data were collected and analysed using SPSS v.11. 3)Pericardial involvement occurred in 5.97%, the ratio Male:Female was 1.7 and the mean age 40.5 years (28.6% between 21-30 years). 14.3% didn't show any general sign. Explanatory findings were cardiomegaly (67.5%), pericardial effusion (55%) and micro-voltage (28.5%). 20.4% of our patients showed cardiac tamponade, 15 patients (31%) healed and death occurred in 37% (18 patients).Pericarditis is not rare, especially in HIV-infection and is essentially tuberculous. We neither found relation between serotype and manifestations nor between manifestations and clinical stage.