In recent years, a very important environmental issue all over the world is the disposal of waste tyres. Rubber from waste tyres can be used to replace part of the natural aggregates in conventional concrete, resulting in a product called crumb rubber concrete (CRC). CRC can improve ductility, damping ratio, and energy dissipation, which are the most important parameters in concrete structures resisting earthquakes. However, CRC can have lower compressive strength when compared with conventional concrete. This paper presents an empirical model able to predict CRC compressive strength. The proposed model is verified using 148 different CRC mixes and compared to two previous models. The proposed model resulted in CRC strength predictions with only 10.7% mean error. The proposed model reduced the mean error in the predictions by 24.6% compared to the nearest predictions by previous models. This paper can aid structural designers who are considering using CRC as a promising alternative to conventional concrete in seismic zones. Refereed/Peer-reviewed