Thesis (Masters by research(Mechanical and Manufacturing Engineering))--University of South Australia, 2014. Includes bibliographical references (pages 56-70) Poor aqueous solubility of some drug molecules is one of the major problems in drug formulations, resulting in many new drugs being withdrawn during the developmental stage due to their poor aqueous solubility. Drug nanosuspensions present a solution to delivering hydrophobic drugs. Scaling down to the nanoparticle range enhances drug aqueous solubility and bioavailability by increasing drug surface area in contact with biological media.