To investigate the inhibitory effects of Pomegranate peel extracts (PPE) on experimental prostatitis rats.The Prostatitis model was established by injection of carrageenan and Staphylococcus aureus in rat prostate. After 9 days' treatments of PPE, the rats were sacrificed for measurement of the number of white blood cell (WBC), the density of lecithin, the levels of Zn and malondialdehyde (MDA) of prostate. The antioxidant capacity was measured by oxygen radical absorbance capacity (ORAC) assay. The levels of NO and the activity of acid phosphatase (ACP) of plasma were also measured.PPE increased the levels of ORAC in plasma and the density of lecithin and the levels of Zn, decreased the levels of MDA of prostate and the activity of ACP and the number of WBC and adjusted the levels of NO in plasma compared with the prostatitis model group (P < 0.05 or P < 0.01).PPE can markedly improve the protective function of oxidation resistance, it may involve its regulatory action on anti-oxidation.