Nocardia is a rare, but serious cause of infection in immunosuppressed patients. Pulmonal nocardiosis is the most frequent manifestation. The ability of Nocardia to disseminate haematogenously frequently causes infection in other organs and increases mortality. We present two cases caused by Nocardia: a patient with a cerebral abscess and a patient with bacteremia. The use of 16S rDNA sequencing for identification reduces the time spent on the final diagnosis, why relevant treatment can be initiated early which improves the prognosis.