The Danish government has allocated funding to achieve the goal of replacing 50% of all existing hospital buildings by new facilities. Facing such a building boom, the debate for and against single-patient rooms is in progress. A review of the literature shows that single-patient rooms have a direct impact on patient safety. Patient Safety Leadership Walkrounds and failure modes and effects analysis can be used for identifying risks before designing single rooms in future hospitals. The acuity adaptability model needs to be revised.