[Lethal intravenous infusion of a wound antiseptic containing polyhexanide].

Polyhexamethylene biguanide (PHMB) is considered to be highly histocompatible and is one of the most frequently used wound antiseptics. Only one case of intoxication has been reported so far. The present case of a lethal intoxication is the first fatal incident described where causality is substantiated by a temporal coincidence between application and ascertainable organ damage. The laboratory-chemical and histological investigations verified the toxicity of this substance after intravenous application with the main findings being severe hepatic and pancreatic damage.

Related Organizations

University of Tübingen
Germany

Keywords

Aged, 80 and over, Catheterization, Central Venous, Pancreatitis, Acute Necrotizing, Soft Tissue Infections, Biguanides, Fatal Outcome, Liver, Humans, Medication Errors, Female, Autopsy, Chemical and Drug Induced Liver Injury, Infusions, Intravenous, Pancreas, Disinfectants

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	0
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average