
Used for more than 10 years in addition to physiotherapy, orthopaedic surgery and rehabilitation, biphosphonate therapy has transformed the management of children with severe or moderate form of osteogenesis imperfecta. The authors of this article report indications, administration's way, duration and safety of biphosphonate therapy with uncertainties about persistence in skeleton for many years.
Fracture Healing, Bone Density Conservation Agents, Diphosphonates, Dose-Response Relationship, Drug, Administration, Oral, Infant, Pamidronate, Osteogenesis Imperfecta, Combined Modality Therapy, Long-Term Care, Drug Administration Schedule, Absorptiometry, Photon, Bone Density, Child, Preschool, Humans, Child, Infusions, Intravenous, Physical Therapy Modalities
Fracture Healing, Bone Density Conservation Agents, Diphosphonates, Dose-Response Relationship, Drug, Administration, Oral, Infant, Pamidronate, Osteogenesis Imperfecta, Combined Modality Therapy, Long-Term Care, Drug Administration Schedule, Absorptiometry, Photon, Bone Density, Child, Preschool, Humans, Child, Infusions, Intravenous, Physical Therapy Modalities
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