Alpha-adrenergic activation upregulates expression of relaxin receptor RXFP1 in cardiomyocytes.
Copyright policy )Alpha-adrenergic activation upregulates expression of relaxin receptor RXFP1 in cardiomyocytes.
Cardiac RXFP1 was upregulated upon activation of the alpha(1)-adrenergic receptor (AR) through signal pathways involving protein kinase A and C and ERK. In contrast, beta(1)-AR activation downregulated expression of cardiac RXFP1 and it further counteracted the alpha(1)-AR-mediated RXFP1 upregulation.
- The Heart Research Institute Australia
Receptors, Peptide, Reverse Transcriptase Polymerase Chain Reaction, Mice, Transgenic, Adrenergic beta-Agonists, Receptors, Adrenergic, alpha, Immunohistochemistry, Rats, Receptors, G-Protein-Coupled, Mice, Animals, Newborn, Gene Expression Regulation, Receptors, Adrenergic, beta, Animals, Myocytes, Cardiac, Adrenergic alpha-Agonists, Cells, Cultured
Receptors, Peptide, Reverse Transcriptase Polymerase Chain Reaction, Mice, Transgenic, Adrenergic beta-Agonists, Receptors, Adrenergic, alpha, Immunohistochemistry, Rats, Receptors, G-Protein-Coupled, Mice, Animals, Newborn, Gene Expression Regulation, Receptors, Adrenergic, beta, Animals, Myocytes, Cardiac, Adrenergic alpha-Agonists, Cells, Cultured
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