Immunohistochemical staining of mucin 1 in prostate tissues.
Copyright policy )Immunohistochemical staining of mucin 1 in prostate tissues.
Prostate cancer is a major public health problem in the world. Molecular studies are necessary for the development of prognostic markers in prostate cancer. There is a great interest in mucin studies in treatment development of human malignancies, including prostate cancer. Nevertheless, their expressions in prostate cancer need further investigation.Mucin 1 (MUC1) expression was examined in 100 prostate biopsies and were compared with prostate carcinoma cell lines (DU-145, PC-3, LNCaP) by immunohistochemistry.Biopsies were healthy, tumor, peritumor or presented an intraepithelial neoplasia. Staining of MUC1 was exihibited in PC-3 cells, was higher in DU-145, and was not expressed by LNCaP. Tumor sections presented more positive expression of MUC1 than non-tumor sections.MUC1 expression is correlated with the histological degree of malignancy.
Male, Cytoplasm, Biopsy, Mucin-1, Prostate, Adenocarcinoma, Immunohistochemistry, Gene Expression Regulation, Neoplastic, Gene Expression Regulation, Antigens, Neoplasm, Cell Line, Tumor, Biomarkers, Tumor, Humans
Male, Cytoplasm, Biopsy, Mucin-1, Prostate, Adenocarcinoma, Immunohistochemistry, Gene Expression Regulation, Neoplastic, Gene Expression Regulation, Antigens, Neoplasm, Cell Line, Tumor, Biomarkers, Tumor, Humans
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